Process for preparing peptide synthons
US5077387A · kind A · utility
3Cited by
1References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 29, 1988 |
| Grant date | Dec 31, 1991 |
| Priority date | — |
| Expiry date | Apr 29, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/06
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a process for preparing peptide synthons in which the optical purity of each of the peptides to be condensed is retained. According to this process, a silyl derivative of an amino acid or peptide, which is activated by a complex chloroimmonium salt, a complex coordinated phosphorus halide, oxyhalide salt or a complex oxalyl halide salt, is prepared. The activated peptide is then condensed with an N-silyl amino acid or peptide in which the acid group is protected.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.