Production of the E. coli LT-B enterotoxin subunit in S. typhi
US5079165A · kind A · utility
9Cited by
6References
8Claims
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Key dates
| Filing date | Jun 29, 1988 |
| Grant date | Jan 7, 1992 |
| Priority date | — |
| Expiry date | Jun 29, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/879
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for the cloning and expression of plasmids bearing genes coding for the non-toxic subunit of the heat-laible enterotoxin (LT-B) of E. coli. These plasmids may be cloned into stable avirulent strains of Salmonella typhi and used to make oral bivalent vaccines. Such vaccines may be used to prevent typhoid fever and cholera-like enterotoxin-induced diarrheal disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.