Cephalosporin derivatives and pharmaceutical compositions in which they are present
US5079241A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1989 |
| Grant date | Jan 7, 1992 |
| Priority date | — |
| Expiry date | Oct 13, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C311/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel cephalosporin derivatives with improved pharmacokinetics, corresponding to the formula: ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3 represent a hydrogen atom, or R.sub.1 and R.sub.2 represent a hydrogen atom or a methyl group and R.sub.3 represents a carboxyl group, or ##STR2## form a cyclobutyl group and R.sub.3 represents a carboxyl group; and A and B are different and occupy the meta and para positions of the benzene ring, one representing a hydroxyl group and the other being selected from the groups ##STR3## and --NH--SO.sub.2 --Alk--NH.sub.2 in which Alk denotes a C.sub.2 -C.sub.4 lower alkylene group and also to the pharmaceutically acceptable salts and esters of the said derivatives. It further relates to a process for the preparation of such cephalosporins and to pharmaceutical compositions in which they are present.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.