Intracellular antigen found in subpopulation of CD8.sup.+ T lymphocytes and monoclonal antibody reactive with same
US5079343A · kind A · utility
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Key dates
| Filing date | Jan 5, 1990 |
| Grant date | Jan 7, 1992 |
| Priority date | — |
| Expiry date | Jan 5, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A 15 kd protein antigen is associated with cytoplasmic granules in cytolytic T lymphocytes and natural killer cells. Monoclonal antibodies immunologically reactive with the 15 kd protein and nucleic acid probes encoding polypeptides that are immunologically cross-reactive with the 15 kd protein can be used, e.g., to identify cytolytic lymphocytes in a sample. Cloned cDNA encoding the antigen can be used to produce the antigen.
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