Proteins having growth hormone anabolic properties with reduced effect on carbohydrate metabolism
US5079345A · kind A · utility
11Cited by
0References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 19, 1988 |
| Grant date | Jan 7, 1992 |
| Priority date | — |
| Expiry date | Aug 19, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This specification describes modified growth hormone having substantially diminished insulin-like and diabetogenic potencies relative to the native hormone with retention of substantially all of the anabolic potency of the native hormone. The modified growth hormone has the following structure: (a) elimination of from 1-5 to 1-19 amino acid residues from the amino terminus of the hormone; (b) cleavage of a peptide bond at any point from the carboxy moiety of residue 127 to residue 153; and (c) optionally, elimination of one or more of amino acid residues 128-152 of the hormone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.