Pharmaceutical compositions for the prevention and treatment of oxidant injuries
US5080886A · kind A · utility
17Cited by
6References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 5, 1990 |
| Grant date | Jan 14, 1992 |
| Priority date | — |
| Expiry date | Jan 5, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/446
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The combination of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid with a superoxide dismutase optionally containing a catalase and ascorbic acid provides enhanced protection from oxidant injury. Administration of 6-hydroxy-2,5,7,8-tetramethyl chroman-2-carboxylic acid, SOD, and optionally CAT and/or ascorbic acid prior to or simultaneously with resuming normal blood supply to mammalian tissue following ischemia provides substantial protection from tissue damage that otherwise is observed upon reperfusion. Administration of Vitamin E, SOD, and CAT similarly provide protection from oxidant injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.