Complexes of TC99m radiopharmaceuticals
US5081232A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 16, 1988 |
| Grant date | Jan 14, 1992 |
| Priority date | — |
| Expiry date | May 16, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Complexes useful as radiopharmaceuticals contain the .sup.99m Tc-NO moiety and up to four organic ligands which confer biological target-seeking properties on the complex. Preferred are mono-cationic complexes, particularly having the formula EQU [.sup.99m Tc(NO)L.sub.2 X].sup.+ where X is halide or pseudohalide and L is a bidentate ligand for Technetium, which have interesting properties for use as heart visualizing agents. Examples of ligands include di-(dialkyl and diphenyl)phosphinoethanes and o-phenylenebisdimethylarsine. The complexes may be made by reacting generator eluate pertechnetate with a hydroxylamine salt and with the ligands, preferably in a single step by providing a reaction mixture containing the three reagents optionally in the presence of a reducing agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.