Method for enhancing the safety of metal-ligand chelates as magnetic resonance imaging agents by addition of calcium ions
US5082649A · kind A · utility
9Cited by
3References
15Claims
0Family size
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Inventor
Key dates
| Filing date | Jun 22, 1989 |
| Grant date | Jan 21, 1992 |
| Priority date | — |
| Expiry date | Jun 22, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Paramagnetic chelates, as for example, Gadolinium diethylenetriaminepentaacetic acid (DTPA), manganese, ethylenediaminetetraacetic acid (EDTA), and others used as magnetic resonance imaging contrast agents are more toxic acutely when injected in high concentration or at rapid rates. The use of effective amounts of calcium in the form of, calcium chloride, calcium gluconate, or balanced salt solutions substantially reduces this toxicity without the need to add additional ligand.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.