Pharmaceutical composition for drugs subject to supercooling
US5082655A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 17, 1989 |
| Grant date | Jan 21, 1992 |
| Priority date | — |
| Expiry date | Feb 17, 2009 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB29K2105/0035
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises a biologically active compound dispersed in a matrix which progressively erodes in contact with a liquid environment, the matrix having a melting point below the melting point of the biologically active compound, and the matrix comprising a mixture of PA0 a.) 5% to 100% by weight of a solid water-dispersible polyether diol having a molecular weight from about 1000 to about 20,000, selected from the group consisting of polyethylene glycols and polyethylene oxide-polypropylene oxide block copolymers, and PA0 b.) 95 to 0% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in the aqueous liquid. Dosage forms comprising the sustained release composition are prepared by molding, particularly by injection molding.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.