Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility
US5082847A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 18, 1990 |
| Grant date | Jan 21, 1992 |
| Priority date | — |
| Expiry date | Jul 18, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Carbostyril derivatives of Formula I: ##STR1## wherein: m is 0, 1, or 2; PA0 n is 0, 1, or 2; PA0 R.sup.1 is hydrogen or lower alkyl; PA0 R.sup.2 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, aralkoxy, or acyloxy; PA0 R.sup.3 is hydrogen, halogen, lower alkyl, or lower alkoxy; PA0 R.sup.4 is hydrogen, hydroxy, lower alkyl, acyloxy, provided that when R.sup.4 is hydroxy or acyloxy, m and n are both 1; PA0 R.sup.5 is hydrogen or lower alkyl; and PA0 R.sup.6 is alkyl, hydroxyalkyl, alkoxyalkyl, or (dialkylamino)alkyl; and the pharmaceutically acceptable acid addition salts and N-oxides (at the carbostyril nitrogen) thereof, and compositions containing them, are useful in treating cardiovascular diseases, particularly arrhythmias. Methods of preparing intermediates, the compounds, their formulations and methods of treatment therewith are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.