Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase

US5084449A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Joachim K. Seydel · Kellinghusen, DE
• Helmut Pieper · Lohr am Main, DE
• Gerd Kruger
• Klaus Noll · Cologne, DE
• Johannes Keck · Zell am Harmersbach, DE
• Uwe Lechner · Biberach an der Riß, DE

Key dates

• Filing date: Dec 7, 1990
• Grant date: Jan 28, 1992
• Expiry date: Dec 7, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are substituted bis(4-aminophenyl-sulfonees of general formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or cycloalkyl; group, PA0 R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl, PA0 R.sub.3 is nitrile, C.sub.1 -C.sub.3 alkylaminocarbonyl, di C.sub.1 -C.sub.3 alkylaminocarbonyl, C.sub.3 -C.sub.7 N-cycloalkyl-C.sub.1 -C.sub.3 alkylaminocarbonyl C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3, di alkylaminocarbonyl alkoxy, alkylaminosulfonyl, di C.sub.1 -C.sub.3 alkylaminono, diC.sub.1 -C.sub.3 alkylaminosulfonyl, hydroxy C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkylcarbonyl, amino C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy C.sub.1 -C.sub.3 alkyl group PA0 or, when R.sub.1 and R.sub.2 are each hydrogen, R.sub.3 can be hydroxy, hydroxycarbonyl C.sub.1 -C.sub.3 alkoxy or di C.sub.1 -C.sub.3 aminocarbonylalkoxy; PA0 or, when R.sub.1 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 cycloalkyl and R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl, R.sub.3 can also be halogen, trifluoromethyl, nitro, amino, aminosulfonyl, aminocarbonyl, C.sub.1 -C.sub.3 alkylo, carboxy or C.sub.1 -C.sub.3 akoxycarbonyl; and PA0 R.sub.4 is hydrogen or, when R.sub.1 and R.sub.2 are each hydrogen an…