1H, 3H-pyrrolo[1,2-c]thiazole-7-carboxamide derivatives and pharmaceutical compositions containing them

US5086051A · kind A · utility

Assignee

• Rhone-Poulenc Sante · FR

Inventors

• Claude James · Paris, FR
• Daniel Lave · Paris, FR
• Francoise Soler · Paris, FR

Key dates

• Filing date: Mar 14, 1990
• Grant date: Feb 4, 1992
• Expiry date: Mar 14, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New derivatives of formula (I) in which R.sub.1 =H, halogen, alkyl, alkyloxy, CF.sub.3, NH.sub.2, alkylamino, dialkylamino, OH, CH, phenyl or phenoxy, Ar=phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, thienyl, thieno[2,3-b]thienyl or thieno[3,2-b]thienyl (these groups optionally substituted with halogen, alkyl, alkyloxy, CF.sub.3, NH.sub.2, alkylamino, dialkylamino, OH or CN), p=0, 1 or 2, and PA0 A--either Z=valency bond and R.sub.2 =H PA0 B--or Z=valency bond and R.sub.2 =pyridyl, quinuclidinyl, 3-pyrrolidinyl, 3- or 4-piperidyl (these groups optionally being substituted with alkyl, hydroxyalkyl, phenyl or phenylalkyl) PA0 C--or Z=alkylene radical (1 to 4C) and R.sub.2 =2-, 3- or 4-pyridyl, 3-quinuclidinyl, 2- or 3-pyrrolidinyl, 2-, 3- or 4-piperidyl (optionally substituted with alkyl, hydroxyalkyl, phenyl or phenylalkyl) or R.sub.2 =CON(R.sub.3)(R.sub.4) where PA1 a) either R.sub.3 and R.sub.4 form a piperazine optionally substituted with alkyl, hydroxyalkyl, pyridyl, phenyl or phenylalkyl, PA1 b) or R.sub.3 =H, alkyl, phenyl or phenylalkyl, or (CH.sub.2).sub.n N(R.sub.5) (R.sub.6) where 1<n<4 and R.sub.5 and R.sub.6 =H, alkyl, phenyl, phenylalkyl, or R.sub.5 and R.sub.6 form…