Inhibitors of retroviral protease with a ketomethylene isosteric replaced amide bond
US5086165A · kind A · utility
23Cited by
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Key dates
| Filing date | Feb 7, 1991 |
| Grant date | Feb 4, 1992 |
| Priority date | — |
| Expiry date | Feb 7, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16222
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are compounds of the class of peptides having from about 4 to about 8 amino acid residues that are substrates for retroviral protease, e.g., HIV protease, derived from known cleavage sites and that are modified to contain an internal COCH.sub.2 bond isostere, useful as inhibitors of said retroviral protease, e.g., HIV protease, and exemplified by the modified peptide, Abz-Thr-Ile-Nle.PSI.(K)Nle-Gln-Arg-NH.sub.2, wherein K is COCH.sub.2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.