Microbial transformation process for producing an antihypertensive product
US5087702A · kind A · utility
7Cited by
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6Claims
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Key dates
| Filing date | Jan 30, 1991 |
| Grant date | Feb 11, 1992 |
| Priority date | — |
| Expiry date | Jan 30, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Fermentation of the microorganism Streptomyces sp. (MA6750) ATCC No. 55042 in the presence of the Angiotensin II (A II) receptor antagonist of the following structure: ##STR1## yields an analog having a shikimate sugar-like moiety attached to the tetrazole, the said analog which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II angatonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.