Process for synthesis of FK-506 intermediates
US5087703A · kind A · utility
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Key dates
| Filing date | Apr 11, 1990 |
| Grant date | Feb 11, 1992 |
| Priority date | — |
| Expiry date | Apr 11, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/33
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is described for the synthesis of diastereomeric 2-methyl-4-hydroxy-5-protected-hydroxy-hept-6-en-prolinolamides, which are useful as intermediates in the synthesis of the C.sub.10 -C.sub.18 chain of the macrolide structure for the immunosuppressant FK-506. These compounds are also useful as intermediates for preparing lactone ultraviolet radiation absorbers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.