Transdermal therapeutical system comprising physostigmine as active component and process for the production thereof

US5089267A · kind A · utility

Assignees

• LTS Lohmann Therapie-Systeme GmbH Co. KG · DE
• Klinge Pharma GmbH · DE

Inventors

• Thomas Hille · Neuwied, DE
• Hans-Rainer Hoffmann · Neuwied, DE
• Hans-Joachim Huber · Hersbruck, DE
• Axel Koch · Hersbruck, DE
• Gerhard Schneider · Baldham, DE
• Fritz Stanislaus · Munich, DE

Key dates

• Filing date: Dec 18, 1989
• Grant date: Feb 18, 1992
• Expiry date: Dec 18, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a cover layer which is impermeable to active substances, a pressure-sensitive adhesive reservoir layer, and optionally a removable protective layer, said reservoir layer consisting of 10-90% polymeric material selected from the groups consisting of block copolymers on the basis of styrene and 1,3-dienes, polyisobutylenes, polymers on the basis of acrylates and/or methacrylates and esters of hydrogenated colophonium, 0-30%-wt softeners on the basis of hydrocarbons and/or esters, and 0.1-20%-wt physostigmine.