.beta.-(4-isopropenylphenyl)estra-4,9-dienes, their production, and pharmaceutical preparations containing same

US5089488A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Eckhard Ottow · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Gunter Neef · Berlin, DE
• Sybille Beier · Berlin, DE
• Walter Elger · Berlin, DE
• David Henderson · Berlin, DE

Key dates

• Filing date: Oct 11, 1990
• Grant date: Feb 18, 1992
• Expiry date: Oct 11, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J41/0094
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

11 .beta.-(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I ##STR1## wherein X is an oxygen atom or a hydroxyimino grouping ##STR2## R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or an acyl residue of 1-10 carbon atoms, PA0 R.sup.3 is a hydrogen atom, the cyanomethyl group, --(CH.sub.2).sub.n --, CH.sub.2 Z, --CH.dbd.CH--(CH.sub.2).sub.m Z or --C.dbd.CC--Y wherein n=0 to 5 and m=1 to 4, Z meaning a hydrogen atom or the OR.sup.4 group with R.sup.4 meaning a hydrogen atom, an alkyl or alkanoyl group each of 1-4 carbon atoms, and Y meaning a hydrogen, chlorine, fluorine, iodine or bromine atom, an alkyl, hydroxyalkyl, alkoxyalkyl or acyloxyalkyl group each of 1-4 carbon atoms in the alkyl or acyl residue, possess antiprogestational activity, e.g., for treating hormonal dependent tumors, and also antiglucocorticoidal activity.