Process for the manufacture of apolipoproteins from human blood plasma or serum
US5089602A · kind A · utility
59Cited by
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16Claims
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Key dates
| Filing date | Mar 11, 1991 |
| Grant date | Feb 18, 1992 |
| Priority date | — |
| Expiry date | Mar 11, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Apolipoproteins are isolated from human blood plasma fractions which contain apolipoproteins by suspending these fractions in buffer solutions. The suspensions are subsequently incubated with a lower aliphatic alcohol, either with or without an organic solvent. The phase which contains the lipoproteins is separated and concentrated. The products obtained according to the procedure may be used primarily for the treatment of cardiovascular diseases, in particular hypercholesterolemia.
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