11 .beta.-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them

US5089635A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gunter Neef · Berlin, DE
• Sybille Beier · Berlin, DE
• Walter Elger · Berlin, DE
• David Henderson · Berlin, DE
• Eckard Otto · Berlin, DE
• Ralph Rohde · Berlin, DE

Key dates

• Filing date: Feb 7, 1986
• Grant date: Feb 18, 1992
• Expiry date: Feb 7, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J53/004
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

13-alkyl-11.beta.-phenyl-gonanes of general formula I ##STR1## wherein A and B together stand for an oxygen atom, a CH.sub.2 group or a second bond between carbon atoms 9 and 10, PA0 X is an oxygen atom or the hydroxyimino grouping N.about.OH, PA0 R.sub.1 is a straight-chained or branched, saturated or unsaturated alkyl radical with up to 8 carbon atoms, which contains the grouping ##STR2## with X as described above, R.sub.2 is a methyl or ethyl radical in the .alpha. or .beta. position, PA0 R.sub.9, R.sub.10, R.sub.11 and R.sub.12 each stand for a hydrogen atom, a hydroxy, alkyl, alkoxy or acyloxy group with 1 to 4 carbon atoms respectively or a halogen atom and R.sub.3 and R.sub.4 have a variety of meanings, have antigestagenic and antiglucocorticoid effects.