Process for the preparation of aryl-substituted propionic acid esters
US5089656A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 18, 1990 |
| Grant date | Feb 18, 1992 |
| Priority date | — |
| Expiry date | Jul 18, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/347
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a process for the preparation of aryl-substituted propionic acid esters having the formula: ##STR1## wherein R and R.sup.1 are a C.sub.1 -C.sub.12 linear or branched alkyl, a C.sub.5 -C.sub.12 cycloalkyl, a C.sub.6 -C.sub.12 aryl or a C.sub.7 -C.sub.12 alkaryl or aralkyl, R.sup.2 is hydrogen or a C.sub.1 -C.sub.20 linear or branched alkyl and R.sup.3 is a C.sub.1 -C.sub.20 linear or branched alkyl, a C.sub.5 -C.sub.12 cycloalkyl, a C.sub.6 -C.sub.12 aryl or a C.sub.7 -C.sub.20 alkaryl or aralkyl, and may be the same or different, which comprises forming a reaction mixture of a phenol, at least one base catalyst and an acrylate, in the presence of a complexing agent effective in increasing the rate of reaction, wherein (i) substantially all of the side-product is removed from said reaction mixtrue prior to the addition of the complexing agent and (ii) all or substantially all of the acrylate is added at once to the reaction mixture. The process results in higher yields of the desired product, in a shorter period of time, with a reduction of undesirable by-products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.