Protection against rhabdomyolysis-induced nephrotoxicity
US5091180A · kind A · utility
32Cited by
0References
14Claims
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Assignee
Inventors
Key dates
| Filing date | Nov 30, 1990 |
| Grant date | Feb 25, 1992 |
| Priority date | — |
| Expiry date | Nov 30, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y115/01001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to the in vivo use of compounds which prevent the generation of, effectively scavenge, or detoxify a reactive oxygen metabolite that mediates a toxic effect of rhabdomyolysis and myoglobinuria. The compounds of the invention can be used to prevent or reduce rhabdomyolysis-induced renal damage, and include but are not limited to free radical scavengers, iron chelators, oxidizable compounds, enzymes which metabolize reactive oxygen metabolites or their precursors, and biosynthetic precursors thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.