Agent for the therapy of factor VIII-resistant hemophilia A, and a process for the preparation thereof

US5091363A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Norbert Heimburger
• Karlheinz Wenz · Weimar, DE
• Wilfried Wormsbacher · Kirchhain, DE

Key dates

• Filing date: Aug 10, 1988
• Grant date: Feb 25, 1992
• Expiry date: Aug 10, 2008

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/83
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An agent for the therapy of hemophilia A which is resistant to treatment with factor VIII is described, and is obtainable by maintaining a mixture of factor VIII, antithrombin III, a phospholipid and calcium ions in an aqueous solution at a temperature of from 1.degree. to 45.degree. C. for at least one minute, adding factor IX, and maintaining the solution at a temperature offrom 1.degree. to 45.degree. C. until addition of a sample of this solution to an inhibitor plasma results in a partial thromboplastin time (PTT) of 15 to 30 seconds, where appropriate adding a polyol and, where appropriate, an amino acid, and, where appropriate, drying the solution.