Cyclic peptides as promoters of absorption on administration onto the mucosa

US5091365A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Jurgen K. Sandow · Königstein, DE
• Rainer Schmiedel · Kelkheim, DE
• Klaus Wirth · Frankfurt am Main, DE
• Hans P. Merkle · Zürich, CH
• Suzanne Raehs · Bonn, DE

Key dates

• Filing date: Aug 5, 1988
• Grant date: Feb 25, 1992
• Expiry date: Aug 5, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the use of aids of the general formula ##STR1## in which B denotes a basic amino acid, A/B denotes an acidic or basic amino acid, X denotes a neutral and hydrophilic amino acid, L denotes a lipophilic neutral amino acid, and R denotes hydrogen or an acyl radical, or the physiologically tolerated salts thereof, for promoting the absorption of peptides and proteins on administration onto the mocosa, as well as to pharmaceutical compositions which contain a pharmacologically effective amount of one or more peptides or proteins as well as an aid of the abovementioned formula.