Thioformamidines, their preparation and use as medicaments
US5091415A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 15, 1990 |
| Grant date | Feb 25, 1992 |
| Priority date | — |
| Expiry date | Oct 15, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Formamidine compounds of general formula I ##STR1## in which: R.sub.1 represents H or C.sub.1-4 alkyl, PA0 R.sub.2 represents benzoyl, benzyl, or alpha-hydroxybenzyl, the aromatic ring being optionally substituted by a halogen atom, PA0 R.sub.3 and R.sub.4, which are identical or different, represent hydrogen, lower-alkyl, or lower-alkenyl, or form between them with the formamidine function a heterocycle, PA0 R.sub.5 represents hydrogen or C.sub.1-4 lower-alkyl or forms with R.sub.4 a double bond (--N.dbd.R.sub.4) in the case of pseudoaromatic heterocycles, PA0 n equals 0 or 1, PA0 A represents a linear or branched C.sub.1-4 alkylene chain, PA0 X represents hydrogen, halogen, C.sub.1-4 lower-alkyl, C.sub.1-4 lower-alkoxy, or nitro, and pharmaceutically-acceptable salts thereof, are disclosed. The compounds and pharmaceutical compositions thereof are used, optionally in combination with other active principles, as drugs for the treatment of gastrointestinal ailments, especially as gastric antisecretory and antiulcer agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.