Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US5091428A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 7, 1991 |
| Grant date | Feb 25, 1992 |
| Priority date | — |
| Expiry date | Feb 7, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: ##STR1## wherein: R.sup.1 is aryl, lower alkyl, cycloalkyl or hydrogen; PA1 R.sup.2 is aryl, lower alkyl or hydrogen; PA1 R.sup.3 is lower alkyl, hydroxy, or hydrogen; PA1 R.sup.4 is aryl or hydrogen; PA1 R.sup.5 is aryl or hydrogen; PA1 m is two or three; PA1 n is zero, one or two, provided that when R.sup.3 is hydroxy, n is one or two; and PA1 q is zero, one, two, or three; and the pharmaceutically acceptable salts thereof, are calcium channel antagonists useful for treating mammals having a variety of disease states, such as stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism and also for treatment of spinal injuries.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.