Derivatives of 4-amino-1-trifluoromethyltetralines their preparation and their therapeutic application
US5091429A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 22, 1989 |
| Grant date | Feb 25, 1992 |
| Priority date | — |
| Expiry date | Jul 22, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Derivatives of 4-amino-1-trifluoromethyltetralines of general formula: ##STR1## wherein: X represents an aromatic nucleus, namely phenyl, naphthyl, or thienyl able to carry one to two substituents chosen from halogeno, hydroxy, C.sub.1 to C.sub.8 alkoxy or trifluoromethyl; PA0 R.sub.1 represents a hydrogen atom or a halogen, a hydroxy group, a C.sub.1 to C.sub.8 alkoxy group, in one of positions 5, 6 or 7, or even a methylenedioxy group in positions 5 and 6 or 6 and 7; PA0 R.sub.2 represents a hydrogen atom or a halogen, a hydroxy group, a C.sub.1 to C.sub.8 alkoxy group in one of the other positions 5, 6 or 7, and PA0 R.sub.3 and R.sub.4 each represent a hydrogen atom, a methyl group or a linear or branched C.sub.1 to C.sub.n alkyl group, n being 2 or more, possibly halogenated, hydroxylated or aminated, or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are linked form a saturated heterocyclic compound, possibly substituted, with five or six atoms of which one or two are heteroatoms chosen from nitrogen, oxygen or sulfur.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.