Cis-platinum complexes, a process for the preparation thereof, and pharmaceuticals containing these compounds

US5091521A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Cenek Kolar · Marburg, DE
• Konrad Dehmel · Marburg, DE
• Hans Kraemer · Marburg, DE

Key dates

• Filing date: Aug 28, 1990
• Grant date: Feb 25, 1992
• Expiry date: Aug 28, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F15/0093
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the general formula I ##STR1## in which R.sup.1 represents a hydrogen atom or an alkyl group of the formula CH.sub.3 (CH.sub.2).sub.n --where n=0 to 5, PA0 R.sup.2 represents a hydrogen atom when X is a carbamoyl group, an alkyl group having 1 to 6 carbon atoms, a group, bonded in an ether-like fashion, of the formula R.sup.3 --O--CH.sub.2 --(CHR.sup.4).sub.m --CH.sub.2 -- in which PA0 R.sup.3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, PA0 R.sup.4 is a hydroxyl group or an alkyloxy group having 1 to 3 carbon atoms, and m is 0 to 2, represents a group, bonded in an ether-like fashion, of the formula H--(CH.sub.2).sub.a --(O--(CH.sub.2).sub.b).sub.c -- where a=0 to 4, b=1 to 4 and c=1 to 7, or PA0 R.sup.2 represents a radical, bonded in a O-glycoside fashion of the formula ##STR2## in which R.sup.5, R.sup.6 and R.sup.7, independently of one another, are a hydrogen atom or a hydroxyl group, and PA0 R.sup.8 is a hydrogen atom, a methyl group or a hydroxy methyl group, PA0 X represents a methylene group or a carbamoyl group or a covalent bond between R.sup.1 and the 2-carbon atom, PA0 A.sup.1 and A.sup.2 are indentical and represent the hydroxyl group,…