6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as .alpha. adrenergic agents
US5091528A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 12, 1990 |
| Grant date | Feb 25, 1992 |
| Priority date | — |
| Expiry date | Sep 12, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds having .alpha. adrenergic activity and useful for the treatment of glaucoma, renal and gastrointestinal disorders and vasoconstictors have the formula ##STR1## where R.sub.1 is independently H, or lower alkyl or 1 to 6 carbons; R.sub.2 is independently H, or lower alkyl of 1 to 6 carbons or the two R.sub.2 symbols jointly represent a carbonyl oxygen; R.sub.3 is H, lower alkyl of one to 6 carbons, O, OH and OR.sub.7 where R.sub.7 is lower alkyl of 1 to 6 carbons, or R.sub.3 is COH or COR.sub.8 where R.sub.8 is lower alkyl of 1 to 6 carbons; R.sub.4 and R.sub.5 independently is H, Br, Cl, or lower alkyl of 1 to 6 carbons, lower alkenyl or lower alkynyl with the proviso that when the R.sub.2 groups symbolize a carbonyl oxygen then R.sub.4 and R.sub.5 both cannot be hydrogen; R.sub.6 is hydrogen, Br, Cl, or lower alkyl of 1 to 6 carbons, lower alkenyl or lower alkynyl, and the R.sub.5 and the (2-imidazoline-2-yl)amino substituents are connected mutually exclusively to the 6 and 7 positions of the 1,4-benzoxazine nucleus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.