Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
US5091541A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 24, 1990 |
| Grant date | Feb 25, 1992 |
| Priority date | — |
| Expiry date | Oct 24, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are disclosed various compounds of the formula below, ##STR1## where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl; PA0 Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl; PA0 R.sub.1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl, heteroaryl or heteroarylloweralkyl; PA0 R.sub.2 is hydrogen, loweralkyl or arylloweralkyl; PA0 R.sub.3 is loweralkyl or arylloweralkyl; PA0 R.sub.4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl; PA0 R.sub.5 is hydrogen or loweralkyl; and PA0 m is 0 or 1, with the proviso that when m is O, R.sub.1 may also be hydrogen. which compounds are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.