Process for the preparation of alkyl 4-oxobutyrate and its acetals
US5091559A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 8, 1988 |
| Grant date | Feb 25, 1992 |
| Priority date | — |
| Expiry date | Feb 8, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/36
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is disclosed for forming alkyl 4-oxobutyrates and its acetals which comprises reacting under anhydrous conditions acrolein or its acetals with carbon monoxide and an alcohol of the formula R OH wherein R is lower alkyl in the presence of a catalytically effective amount of a catalyst comprising palladium metal which is either unsupported or supported on an inert carrier and a promoting effective amount of hydrogen halide. An intermediate in the process, i.e., .beta.-halopropionaldehyde or acetal thereof can also be used in forming alkyl 4-oxobutyrates and acetals thereof by reacting under anhydrous conditions said .beta.-halopropionaldehyde or its acetals with carbon monoxide and an alcohol of the formula ROH wherein R is lower alkyl in the presence of a catalytically effective amount of a catalyst comprising palladium metal which is either unsupported or supported on an inert carrier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.