Reagents for detecting oxidase positive microorganisms
US5093239A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 2, 1988 |
| Grant date | Mar 3, 1992 |
| Priority date | — |
| Expiry date | May 2, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/40
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds and reagents containing the compounds are disclosed for detecting oxidase positive organisms. The compounds have the structure EQU COUP--LINK).sub.n R wherein PA1 COUP-- represents a radical that couples with an oxidized primary aromatic amine and releases --LINK--R; PA1 --LINK-- represents a divalent radical that undergoes intramolecular cyclization and release of --R upon release by COUP--; PA1 n represents zero or one; PA1 --R represents a monovalent radical that forms a detectable species in the form of a colorimetric dye or fluorescent compound upon release from --LINK--; wherein --R is selected from the group consisting of: ##STR1## wherein W represents hydrogen; halogen; hydroxy; substituted or unsubstituted carbonamido; sulfonamido; sulfonyl; ureido or amino; PA1 R.sup.1 and R.sup.2 each independently represent hydrogen, halogen, alkyl, alkoxy, carboxy, sulfo, cyano, nitro, carboxylic acid ester, carbonyl, sulfonyl, carbonamido, sulfonamido, alkylsulfonyl, arylsulfonyl; and PA1 R.sup.3 and R.sup.4 each independently represent halogen, nitro, sulfonamido, sulfonyl, carbonamido, carbonyl, cyano, alkylsulfonyl, arylsulfonyl; PA1 R.sup.6 represents H, CH.sub.3 or C.su…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.