Process for the preparation of halogenomethylketones, in particular of 1,1,1-trifluoroacetone

US5093532A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Bernd Baasner · Bensberg, DE
• Jens-Peter Lorentzen · Cologne, DE

Key dates

• Filing date: Jul 31, 1991
• Grant date: Mar 3, 1992
• Expiry date: Jul 31, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C49/167
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Halogenomethylketones are prepared from nitro compounds by treating the latter in alcoholic solution with sodium alkoxide or potassium alkoxide, cooling to a temperature in the range -10.degree. to -100.degree. C. and then allowing the mixture to react with ozone at -10.degree. to -100.degree. C. The process is particularly suitable for the preparation of 1,1,1-trifluoroacetone from 1,1,1-trifluoro-2-nitropropane.