Calcification-resistant materials and methods of making same through use of trivalent aluminum
US5094661A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 1, 1988 |
| Grant date | Mar 10, 1992 |
| Priority date | — |
| Expiry date | Apr 1, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/92
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Bioprosthetic materials, either natural or synthetic, are treated with trivalent aluminum cations to prevent in vivo calcification. Such bioprosthetic materials include porcine aortic valve leaflets, bovine pericardium, aortic homografts, biocompatible elastomers, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Simple incubation of the natural bioprosthetic materials in an aluminum ion-containing solution, such as aqueous AlCl.sub.3, prior to implantation has been found to inhibit calcification of the biomaterial over a prolonged period and to do so without adverse side effects. Incorporation of an aluminum-containing compound into the formulation for polymers, such as polyurethane, has also been found to inhibit calcification with no adverse side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.