Oxytocin and vasopressin antagonists

US5095003A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Michael A. Goetz · Scotch Plains, US
• Lawrence Koupal · Colonia, US
• Cheryl D. Schwartz · Westfield, US
• Jerrold M. Liesch · Princeton Junction, US
• Otto D. Hensens · Red Bank, US
• Paul S. Anderson · Lansdale, US
• Roger M. Freidinger · Hatfield, US
• Douglas J. Pettibone · Doylestown, US

Key dates

• Filing date: Oct 23, 1990
• Grant date: Mar 10, 1992
• Expiry date: Oct 23, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/465
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.