Protective four amino acid epitope against Plasmodium vivax malaria
US5095093A · kind A · utility
2Cited by
5References
4Claims
0Family size
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Key dates
| Filing date | Nov 6, 1990 |
| Grant date | Mar 10, 1992 |
| Priority date | — |
| Expiry date | Nov 6, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A synthetic peptide of the human malaria Plasmodium vivax, containing at st one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoites of the human maleria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented. Also described are pharmaceutical formulations of these peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.