Magnetic protein conjugates, a process for the preparation thereof and the use thereof

US5095097A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Peter Hermentin · Marburg, DE
• Reiner Donges · Gladenbach, DE
• Udo Franssen · Marburg, DE
• Karlheinz Enssle · Marburg, DE
• Heinz-Jurgen Friesen · Lahntal, DE

Key dates

• Filing date: Jun 15, 1990
• Grant date: Mar 10, 1992
• Expiry date: Jun 15, 2010

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2446/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to magnetic protein conjugates of the formula I EQU M--NH--CO--(CH.sub.2).sub.n --S--P' I with n=1-6, preferably with a n=1 or 2 and particularly preferably with n=1, in which M is a dispersible, magnetically reacting material or particle which carries amino groups, and P' is a protein, to a process for the preparation thereof and to the use thereof for the specific removal of cells or soluble antigens, receptors, substrates, cofactors or carbohydrate determinants from aqueous salt solutions or body fluids or as part of a diagnostic method or as a diagnostic aid, preferably for the removal of cells, preferably for bone marrow depletion or for HLA typing.