Patent · US Expired

Process for the preparation of D-(+)-biotin

US5095118A · kind A · utility

3Cited by

2References

3Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Eike Poetsch · Mühltal, DE
Michael Casutt · Pfungstadt, DE

Key dates

Filing date	Apr 13, 1990
Grant date	Mar 10, 1992
Priority date	—
Expiry date	Apr 13, 2010

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D513/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

D-(+)-biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in Patent claim 1, in a simple, stereospecific manner. Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.