Preterm labor and membrane rupture test
US5096830A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 15, 1988 |
| Grant date | Mar 17, 1992 |
| Priority date | — |
| Expiry date | Sep 15, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/814
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for determining increased risk of labor and fetal membrane rupture after week 20 of pregnancy comprises obtaining a secretion sample from the vaginal cavity; and determining the presence of a fetal restricted antigen in the sample. The sample can be removed from anywhere in the vaginal cavity, but is preferably removed from the posterior fornix or and/or cervical os. One fetal restricted antigen is fetal fibronectin. In one embodiment of this invention, the sample is contacted with an insoluble support to which anti-(fetal restricted antigen) antibody is adhered, and the fetal restricted antigen binding to the support is determined. Alternatively, the class of substances of which the fetal restricted antigen is a member is captured with a general binding antibody (such as anti-human fibronectin antibody), anti-(fetal restricted antigen) antibody (such as anti-fetal fibronectin antibody) is conjugated with the support, and binding with fetal restricted antigen is determined. Reagents and reagent kits are also included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.