Oxapenem-3-carboxylic acids

US5096899A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hans Rudolf Pfaendler · Planegg, DE
• Wolfram Hendel · Leonding, AT

Key dates

• Filing date: Aug 24, 1990
• Grant date: Mar 17, 1992
• Expiry date: Aug 24, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D503/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the structural formulae ##STR1## and their pharmaceutically acceptable salts, esters and amide derivatives, in which R.sup.1 and R.sup.2, independently of one another, denote hydrogen or pharmaceutically acceptable groups which have 1 to 10 carbon atoms and are bonded to the remaining part of the molecule via carbon-carbon single bonds, and in which R.sup.3, R.sup.4 and R.sup.5, independently of one another, denote pharmaceutically acceptable groups which have 1 to 10 carbon atoms and are bonded to the remaining part of the molecule via carbon-carbon single bonds, are useful antibiotics. The trisubstitution by three groups R.sup.3, R.sup.4 and R.sup.5, which are bonded via carbon-carbon single bonds, results in a noticeable increase in the hydrolysis stability and thus also in the antibacterial action of axapenemcarboxylic acids.