Heterocyclic compounds containing nitrogen and sulfur, pharmaceutical compositions containing them and process for preparing same
US5096902A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1990 |
| Grant date | Mar 17, 1992 |
| Priority date | — |
| Expiry date | Apr 12, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D279/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel nitrogen- and sulfur-containing heterocyclic compounds of the formula (I), acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## Ar stands for an optionally mono- or polysubstituted aryl or heteroaryl group; PA0 R.sup.1 means a carbonyl or (C.sub.2-6 alkenyl)carbonyl group; PA0 R.sup.2 stands for hydrogen C.sub.1-6 alkyl, phenyl or phenyl (C.sub.1-4 alkyl) group; PA0 R.sup.3 means hydrogen or (C.sub.1-6 alkoxy)carbonyl group; PA0 R.sup.4 and R.sup.5 stand, independently from each other, for hydrogen or C.sub.1-6 alkyl group; PA0 R.sub.6 ogen, C.sub.1-6 alkyl group or halophenyl group; PA0 m is 0 or 1; and PA0 n is 1 or 2, with the proviso that R.sup.2 means hydrogen when m is 0. The compounds of formula (I) show a significant cerebral antihypoxic action and thus, they can be used for the treatment of diseases caused by hypoxic brain damages such as e.g. the senile dementia, Alzheimer's disease or disturbances of the cognitive function.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.