Method of inhibiting the activity of leukocyte derived cytokines
US5096906A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 5, 1990 |
| Grant date | Mar 17, 1992 |
| Priority date | — |
| Expiry date | Dec 5, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. Another family of effective compounds is identified as ##STR2## The inhibition of IL-1, TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.