Patent · US Expired

Macrocyclic antibodies

US5096922A · kind A · utility

4Cited by

0References

5Claims

0Family size

Assignee

Gesellschaft fur Biotechnologische Forschung mbH (GBF) · DE

Inventors

Hans Reichenbach · Braunschweig, DE
Gerhard Hofle · Braunschweig, DE
Hermann Augustiniak · Wolfenbüttel, DE
Norbert Bedorf · Königslutter am Elm, DE
Klaus Gerth · Braunschweig, DE
Herbert Irschik · Wittmund, DE
Rolf Jansen · Braunschweig, DE
Brigitte Kunze · Braunschweig, DE
Dietmar Schomburg · Braunschweig, DE
Heinrich Steinmetz · Wennigsen (Deister), DE
Wolfram Trowitzsch-Kienast · Braunschweig, DE
Victor Wray · Braunschweig, DE

Key dates

Filing date	Apr 23, 1990
Grant date	Mar 17, 1992
Priority date	—
Expiry date	Apr 23, 2010

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P19/623
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; PA1 R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy and salts thereof, especially pharmaceutically acceptable salts. The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium cellulosum and are effective antibiotics.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.