Process for crystallizing L-alpha-aspartyl-L-phenyl-alanine methyl ester
US5097060A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 18, 1991 |
| Grant date | Mar 17, 1992 |
| Priority date | — |
| Expiry date | Jun 18, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA23G2200/10
- WIPO fieldFood chemistry
- WIPO sectorChemistry
Abstract
A process for crystallizing L-alpha-aspartyl-L-phenylalanine methyl ester from its aqueous solution by cooling, which comprises adjusting the initial concentration of the ester so that the amount of a precipitated solid phase to be formed after cooling becomes about 10 grams or more per liter of the solvent, cooling the solution through conductive heat transfer through a cooled surface to form an apparently sherbet-like pseudosolid phase without causing forced flow by mechanical stirring or the like, and optionally further cooling the system after formation of the pseudosolid phase, is disclosed along with various apparatuses which may be used to carry out the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.