Nitro-substituted aromatic or hetero-aromatic compounds for use in cancer treatment
US5098921A · kind A · utility
5Cited by
1References
20Claims
0Family size
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Key dates
| Filing date | Dec 2, 1988 |
| Grant date | Mar 24, 1992 |
| Priority date | — |
| Expiry date | Dec 2, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 of from -250 to -500 mV; each of R'.sub.1 to R'.sub.5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclization reaction; or a physiologically acceptable acid addition salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.