6-substituted mitomycin analogs
US5098926A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1989 |
| Grant date | Mar 24, 1992 |
| Priority date | — |
| Expiry date | Dec 13, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a radical of the formula --O--R, wherein R is: PA1 a substituted lower alkyl radical selected from the group consisting of mono- and di-hydroxy lower alkyl, cyano lower alkyl, halo lower alkyl, lower alkyl amino lower alkyl, hydroxy lower alkylthio lower alkyl, hydroxy lower alkyldithio lower alkyl, di-lower alkoxy lower alkyl, hydroxy or lower alkoxy substituted lower alkoxy lower alkyl, cyclo lower alkyl substituted lower alkyl; and lower alkyl substituted dioxolanyl lower alkyl or PA1 a lower alkenyl radical; or PA1 a lower alkynyl radical; or PA1 tetrahydro furanyl or a lower alkyl substituted derivative thereof, oxiranyl lower alkyl, tetrahydropyranyl lower alkyl, or furanyl lower alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.