Binding assay device with removable cassette and manifold
US5100626A · kind A · utility
Inventor
Key dates
| Filing date | May 24, 1990 |
| Grant date | Mar 31, 1992 |
| Priority date | — |
| Expiry date | May 24, 2010 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54366
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The binding assay device of the present invention provides a removable cassette with an array of parallel channels for receiving multiple samples for assay. The cassette generally comprises a substantially planar cassette base with open channels formed in its bottom surface and a pair of channel extensions extending from its top surface which contain closed channels corresponding to and in fluid communication with open channels. The closed channels are further provided with openings at their termini for introduction of test samples into the cassette. In an assembled device, the cassette is disposed between a base plate and a slotted cover plate adapted for receipt of the channel extensions of the cassette. A resilient cushioning pad placed between the cassette base and base plate improves interchannel sealing and reduces the volume of the base channels and samples needed. A removable manifold adapted for sealing engagement with a channel extension and in fluid communication with the channels of the cassette facilitates simultaneous flushing of the channels. In assaying for a analyte, a membrane on which binding member specific for the analyte is immobilized is placed between the re…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.