Controlled release systems containing heparin and growth factors
US5100668A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 14, 1988 |
| Grant date | Mar 31, 1992 |
| Priority date | — |
| Expiry date | Jun 14, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/816
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A system for stabilizing fibroblast-derived growth factors, maintaining their bioactivity over a prolonged period of time and controllably releasing them for use is disclosed. The system uses growth factors bound to biocompatible substrates via heparin or heparin derived compounds to maintain the bioactivity of the growth factors. A growth factor bound to a heparin coated substrate can be used independently as a controlled release device, or can be incorporated into a reservoir or matrix type controlled release devices to further enhance the controlled release properties. The stabilized growth factors can be implanted into a patient, thereby providing a means for producing an in vivo controlled release of a growth factor to the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.