Fluorinated esters of rapamycin
US5100883A · kind A · utility
252Cited by
6References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 8, 1991 |
| Grant date | Mar 31, 1992 |
| Priority date | — |
| Expiry date | Apr 8, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or ##STR2## R.sup.3 is a mono-, di-, poly-, or per-fluorinated alkyl group with the proviso that R.sup.1 and R.sup.2 are both not hydrogen, which by virtue of its immunosuppressive activity is useful in treating transplantation rejection, host vs. graft disease, autoimmune diseases and diseases of inflammation; by virtue of its antitumor activity is useful in treating solid tumors; and by virtue of its antifungal activity is useful in treating fungal infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.