Positive inotropically active 4-quinolyl-dihydropyridines and use thereas

US5100900A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Stoltefuss · Haan, DE
• Horst Boshagen · Haan, DE
• Siegfried Goldmann · Wuppertal, DE
• Alexander Straub · Wuppertal, DE
• Rainer Gross · Wuppertal, DE
• Joachim Hutter · Leverkusen, DE
• Siegbert Hebisch · Wuppertal, DE
• Martin Bechem · Wuppertal, DE

Key dates

• Filing date: Mar 29, 1991
• Grant date: Mar 31, 1992
• Expiry date: Mar 29, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, PA1 R.sup.2 represents nitro or cyano, or PA1 R.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## in which R.sup.6 - denotes hydrogen, halogen or straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms, PA1 R.sup.7 denotes aryl, thienyl or pyridyl, and PA1 R.sup.4 represents hydrogen, or optionally substituted alkyl, alkenyl, alkadienyl or alkynyl, and their physiologically acceptable salts.