Thienyloxyalkylamine derivatives, process for their preparation and medicaments containing them

US5100911A · kind A · utility

Assignee

• Ebewe Arzneimittel Gesellschaft m.b.H. · AT

Inventors

• Dieter Binder · Wien, AT
• Gerhard Greier · Friedrichsdorf, DE
• Franz Rovenszky · Mannersdorf am Leithagebirge, AT
• Friedrich Hillebrand · Neumarkt am Wallersee, AT

Key dates

• Filing date: May 15, 1990
• Grant date: Mar 31, 1992
• Expiry date: May 15, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Thienyloxyalkylamine derivatives of the general formula: ##STR1## wherein --O--CH.sub.2 --CH.sub.2 --NR.sub.2 R.sub.3 is in position 4 or 5 of the thiophene ring; PA0 R.sub.1 is hydrogen, halogen, CF.sub.3, alkyl or alkoxy; PA0 R.sub.2 and R.sub.3 are the same or different and are each alkyl, cycloalkyl, alkenyl or alkynyl each having up to 8 C atoms, or NR.sub.2 R.sub.3 is a 5 to 7-membered saturated heterocyclic ring optionally containing a further hetero atom which is oxygen or nitrogen optionally substituted by an alkyl group having 1 to 3 C atoms; and PA0 n is an integer of 1 to 5; as well as their acid addition salts, are suitable for treatment of heart rhythm disturbances.